Soon, in , ICOS received a patent for compound IC structurally unlike sildenafil and vardenafil , and Phase 1 clinical trials began in Physicians should discuss with patients the potential for CIALIS to augment the blood-pressure-lowering effect of alpha-blockers and antihypertensive medications. Symptoms may include sudden urges to urinate urgency , difficulty in starting urination hesitancy , a weak urine stream, and more frequent urination — especially at night. Your doctor will probably tell you not to take tadalafil if you are taking nitrates. Can Cialis be used with other treatments for impotence?Tadalafil (Cialis) is taken by mouth either as needed before sexual activity or once daily for erectile dysfunction (ED).It’s also taken once daily to treat symptoms from . Tadalafil, or generic Cialis, is most commonly used to treat erectile dysfunction (ED). However, it’s also used to treat benign prostatic hyperplasia (BPH) and pulmonary arterial hypertension. Cialis lasts up to 36 hours in the body, while Viagra lasts 4–6 hours in the body. Both are taken 30 minutes before sex. Cialis can cause limb pain, while Viagra can cause vision change, rash.