How long does Cialis last? A few things can impact how long it takes Cialis to work including other health conditions, other medications you take, your age, your diet and your dose. Generic versions of tablets like Tadalafil need to be proven to work as well as a brand-name medicine in a lab, before they can be sold. This is a serious condition that requires immediate medical attention. Cialis is an orange-yellow, film-coated tablet in the shape of an almond.How to take Cialis Daily If you’re taking the mg or 5mg dose: take one tablet daily, at the same time each day; swallow whole with water; don’t take more than one Cialis pill in any 24 hour period. After a couple of days use, the drug should’ve had time to be taken up into your system. By this time it should be active all the time. Cialis: available in doses of 5, 10, and 20 mg, starting at $65 per tablet; Daily Cialis: 5 mg tablet with pricing starting from $50 per tablet.  · At $ for 30, 5MG Tablet, Cialis is an expensive prescription drug. You can lower the cost of Cialis to $ for 30, 20mg Tablet of generic Cialis. You’ll find free Cialis coupons below from SingleCare to save even more money on your next prescription or refill. Brand vs. Generic.