The two integrated analyses reporting this outcome found significantly better CGI scores compared with placebo at study endpoint. If you buy any medicines, please check with your doctor or a pharmacist that they are suitable for you to take with dapoxetine. Treatment Common treatment options for premature ejaculation include behavioral techniques, medications and counseling. It starts to work very quickly, so it is taken when you anticipate having sex, rather than every day. Before taking dapoxetine Some medicines are not suitable for people with certain conditions, and sometimes a medicine can only be used if extra care is taken. · Dapoxetine oral Updated 2 Feb | Selective serotonin re-uptake inhibitors Premature ejaculation Share Check interactions Drugs List Therapeutic Indications Dosage Contraindications Precautions and Warnings Pregnancy and Lactation Side Effects Monograph Drugs List dapoxetine 30mg tablets dapoxetine 60mg tablets PRILIGY . DrugBank Accession Number. DB Background. Dapoxetine is a selective serotonin reuptake inhibitor, for the treatment of premature ejaculation. In a phase II proof-of-concept study conducted by PPD, dapoxetine demonstrated a statistically significant increase in ejaculatory latency when compared to placebo. Dapoxetine is a short-acting selective serotonin reuptake inhibitor (SSRI) that prolongs intravaginal latency time from less than a minute to an average of over 3 minutes. The mechanism of action is unclear but may involve increased serotonin in the brain stem, modulating pudendal nerve activity via descending pathways.