It can also increase the risk of fainting. Dapoxetine is not recommended in men with severe renal impairment, and caution is advised in men with mild to moderate renal impairment. It increases the time it takes to ejaculate and can improve the control over the ejaculation. You can take it either with or without food. Keywords: premature ejaculation, selective serotonin re-uptake inhibitors SSRIs , dapoxetine, intravaginal ejaculatory latency time IELT Introduction Over the past 20—30 years, the premature ejaculation PE treatment paradigm, previously limited to behavioural psychotherapy, has expanded to include drug treatment. Feeling dizzy or light-headed Sit with your head between your knees, or lie down until the feeling passes Feeling sick nausea , sweaty or confused These are signs that fainting may occur. Dapoxetine is rapidly absorbed and eliminated, resulting in minimal accumulation and has dose-proportional pharmacokinetics, which are unaffected by multiple dosing.Adult. Initially 30 mg, to be taken approximately 1–3 hours before sexual activity, subsequent doses adjusted according to response; review treatment after 4 weeks (or 6 doses) and at least every 6 months thereafter, not recommended for adults 65 years and over; maximum 1 dose per day; maximum 60 mg per day. The maximum dose of dapoxetine should be 30 mg if dapoxetine is combined with any of these drugs (see sections , and below). These two measures apply to all patients unless the patient has been verified to be a CYP2D6 extensive metabolizer by geno- . This paper reviews the current evidence for use of dapoxetine in the treatment of PE in adult men. There is substantial evidence that dapoxetine 30 mg or 60 mg taken “on-demand” results in a significant increase in intravaginal ejaculatory latency time when compared with placebo.