As with other PDE5 inhibitors, tadalafil has mild systemic vasodilatory properties that may result in transient decreases in blood pressure. Cialis: Is one right for you? Patients with severely impaired autonomic control of blood pressure may be particularly sensitive to the actions of vasodilators, including PDE5 inhibitors. Stop and get medical help at once if you have nausea, chest pain, or dizziness during sex. Do not take two doses at one time. Safety of combined use of PDE5 inhibitors and alpha-blockers may be affected by other variables, including intravascular volume depletion and other antihypertensive drugs.Cialis can cost around $ to $ per month out of pocket, depending on the dosage you need. The first generic version of Cialis was released in October , and other manufacturers have released generic versions since then. This has increased market competition, driving prices down. Cialis usually takes about 30 minutes to take effect with sexual stimulation and its effect lasts for up to 36 hours, which is why it is sometimes referred to as a “weekend pill”. Talk with your doctor. You may need to try a different erectile dysfunction medication, such as Viagra, or Levitra. It is possible that a different drug will be. from $2, for 30 tablets Cialis oral tablet from $2, for 30 tablets Cialis Coupons, Copay Cards and Rebates Cialis offers may take the form of printable coupons, rebates, savings or copay cards, trial offers, or free samples.